diff --git a/extensions/amazon-bedrock/index.test.ts b/extensions/amazon-bedrock/index.test.ts
index 7659b60b0d3..e4addeb776b 100644
--- a/extensions/amazon-bedrock/index.test.ts
+++ b/extensions/amazon-bedrock/index.test.ts
@@ -140,4 +140,74 @@ describe("amazon-bedrock provider plugin", () => {
       cacheRetention: "none",
     });
   });
+
+  it("injects region from bedrockDiscovery config into stream options", () => {
+    const provider = registerSingleProviderPlugin(amazonBedrockPlugin);
+    const baseFn = (_model: never, _context: never, options: Record<string, unknown>) => options;
+    const wrapped = provider.wrapStreamFn?.({
+      provider: "amazon-bedrock",
+      modelId: "eu.anthropic.claude-sonnet-4-6",
+      config: {
+        models: {
+          bedrockDiscovery: { region: "eu-west-1" },
+        },
+      },
+      streamFn: baseFn,
+    } as never);
+
+    const result = wrapped?.(
+      {
+        api: "bedrock-converse-stream",
+        provider: "amazon-bedrock",
+        id: "eu.anthropic.claude-sonnet-4-6",
+      } as never,
+      { messages: [] } as never,
+      {},
+    );
+    expect(result).toMatchObject({ region: "eu-west-1" });
+  });
+
+  it("injects region extracted from provider baseUrl into stream options", () => {
+    const provider = registerSingleProviderPlugin(amazonBedrockPlugin);
+    const baseFn = (_model: never, _context: never, options: Record<string, unknown>) => options;
+    const wrapped = provider.wrapStreamFn?.({
+      provider: "amazon-bedrock",
+      modelId: "eu.anthropic.claude-sonnet-4-6",
+      config: {
+        models: {
+          providers: {
+            "amazon-bedrock": {
+              baseUrl: "https://bedrock-runtime.eu-central-1.amazonaws.com",
+              models: [],
+            },
+          },
+        },
+      },
+      streamFn: baseFn,
+    } as never);
+
+    const result = wrapped?.(
+      {
+        api: "bedrock-converse-stream",
+        provider: "amazon-bedrock",
+        id: "eu.anthropic.claude-sonnet-4-6",
+      } as never,
+      { messages: [] } as never,
+      {},
+    );
+    expect(result).toMatchObject({ region: "eu-central-1" });
+  });
+
+  it("does not inject region when neither bedrockDiscovery nor baseUrl is configured", () => {
+    const provider = registerSingleProviderPlugin(amazonBedrockPlugin);
+    const baseFn = (_model: never, _context: never, options: Record<string, unknown>) => options;
+    const result = provider.wrapStreamFn?.({
+      provider: "amazon-bedrock",
+      modelId: "anthropic.claude-sonnet-4-6",
+      streamFn: baseFn,
+    } as never);
+
+    // Without region config, Claude model returns the base streamFn directly
+    expect(result).toBe(baseFn);
+  });
 });
diff --git a/extensions/amazon-bedrock/index.ts b/extensions/amazon-bedrock/index.ts
index 4dc69af95a2..88a7fb622e5 100644
--- a/extensions/amazon-bedrock/index.ts
+++ b/extensions/amazon-bedrock/index.ts
@@ -8,6 +8,15 @@ import {
 const PROVIDER_ID = "amazon-bedrock";
 const CLAUDE_46_MODEL_RE = /claude-(?:opus|sonnet)-4(?:\.|-)6(?:$|[-.])/i;
 
+/** Extract the AWS region from a bedrock-runtime baseUrl, e.g. "https://bedrock-runtime.eu-west-1.amazonaws.com". */
+function extractRegionFromBaseUrl(baseUrl: string | undefined): string | undefined {
+  if (!baseUrl) {
+    return undefined;
+  }
+  const match = /bedrock-runtime\.([a-z0-9-]+)\.amazonaws\.com/.exec(baseUrl);
+  return match?.[1];
+}
+
 export default definePluginEntry({
   id: PROVIDER_ID,
   name: "Amazon Bedrock Provider",
@@ -19,26 +28,58 @@ export default definePluginEntry({
       docsPath: "/providers/models",
       auth: [],
       wrapStreamFn: ({ modelId, config, streamFn }) => {
-        // Look up model name from provider config for inference profile detection.
+        // Look up model name and region from provider config.
         // Use normalized key matching so aliases like "bedrock" / "aws-bedrock" are found.
         let modelName: string | undefined;
+        let providerBaseUrl: string | undefined;
         const providers = config?.models?.providers;
         if (providers) {
           for (const [key, value] of Object.entries(providers)) {
             if (normalizeProviderId(key) !== PROVIDER_ID) {
               continue;
             }
-            const models = (value as { models?: Array<{ id?: string; name?: string }> })?.models;
-            const modelDef = models?.find((m) => m.id === modelId);
+            const typedValue = value as {
+              baseUrl?: string;
+              models?: Array<{ id?: string; name?: string }>;
+            };
+            if (!providerBaseUrl && typedValue.baseUrl) {
+              providerBaseUrl = typedValue.baseUrl;
+            }
+            const modelDef = typedValue.models?.find((m) => m.id === modelId);
             if (modelDef?.name) {
               modelName = modelDef.name;
               break;
             }
           }
         }
-        return isAnthropicBedrockModel(modelId, modelName)
+
+        // Extract region from provider baseUrl or bedrockDiscovery config so the
+        // pi-ai BedrockRuntimeClient uses the correct endpoint. Without this, the
+        // gateway process (which may not inherit AWS_REGION) falls back to us-east-1
+        // and rejects cross-region inference profile IDs like "eu.anthropic.claude-*".
+        const region =
+          config?.models?.bedrockDiscovery?.region ?? extractRegionFromBaseUrl(providerBaseUrl);
+
+        const baseFn = isAnthropicBedrockModel(modelId, modelName)
           ? streamFn
           : createBedrockNoCacheWrapper(streamFn);
+
+        if (!region) {
+          return baseFn;
+        }
+
+        // Wrap to inject the region into every stream call.
+        const underlying = baseFn ?? streamFn;
+        if (!underlying) {
+          return baseFn;
+        }
+        return (model, context, options) => {
+          // pi-ai's bedrock provider reads `options.region` at runtime but the
+          // StreamFn type does not declare it. Merge via Object.assign to avoid
+          // an unsafe type assertion.
+          const merged = Object.assign({}, options, { region });
+          return underlying(model, context, merged);
+        };
       },
       resolveDefaultThinkingLevel: ({ modelId }) =>
         CLAUDE_46_MODEL_RE.test(modelId.trim()) ? "adaptive" : undefined,