diff --git a/src/infra/retry-policy.test.ts b/src/infra/retry-policy.test.ts
index be0e4d91de3..6b74e07ce21 100644
--- a/src/infra/retry-policy.test.ts
+++ b/src/infra/retry-policy.test.ts
@@ -81,6 +81,22 @@ describe("createTelegramRetryRunner", () => {
         expectedCalls: 1,
         expectedError: "permission denied",
       },
+      {
+        name: "retries misdirected request errors from Telegram edge nodes",
+        runnerOptions: {
+          retry: ZERO_DELAY_RETRY,
+        },
+        fnSteps: [
+          {
+            type: "reject" as const,
+            value: Object.assign(new Error("421 Misdirected Request"), {
+              status: 421,
+            }),
+          },
+        ],
+        expectedCalls: 3,
+        expectedError: "421 Misdirected Request",
+      },
       {
         name: "keeps retrying retriable errors until attempts are exhausted",
         runnerOptions: {
diff --git a/src/infra/retry-policy.ts b/src/infra/retry-policy.ts
index e28142b117f..c99596878c6 100644
--- a/src/infra/retry-policy.ts
+++ b/src/infra/retry-policy.ts
@@ -11,7 +11,8 @@ export const TELEGRAM_RETRY_DEFAULTS = {
   jitter: 0.1,
 };
 
-const TELEGRAM_RETRY_RE = /429|timeout|connect|reset|closed|unavailable|temporarily/i;
+const TELEGRAM_RETRY_RE =
+  /429|421|timeout|connect|reset|closed|unavailable|temporarily|misdirected request/i;
 const log = createSubsystemLogger("retry-policy");
 
 function resolveTelegramShouldRetry(params: {