diff --git a/extensions/voice-call/index.ts b/extensions/voice-call/index.ts
index ad63cf1f52a..1b887707119 100644
--- a/extensions/voice-call/index.ts
+++ b/extensions/voice-call/index.ts
@@ -50,6 +50,16 @@ const voiceCallConfigSchema = {
     "telnyx.publicKey": { label: "Telnyx Public Key", sensitive: true },
     "twilio.accountSid": { label: "Twilio Account SID" },
     "twilio.authToken": { label: "Twilio Auth Token", sensitive: true },
+    "twilio.region": {
+      label: "Twilio Region",
+      help: "Processing region: ie1 (Ireland) or au1 (Australia). Omit for US1 (default). Requires region-specific auth credentials.",
+      advanced: true,
+    },
+    "twilio.edge": {
+      label: "Twilio Edge Location",
+      help: "Edge location (e.g. dublin, sydney, ashburn). Auto-inferred from region if omitted.",
+      advanced: true,
+    },
     "outbound.defaultMode": { label: "Default Call Mode" },
     "outbound.notifyHangupDelaySec": {
       label: "Notify Hangup Delay (sec)",
diff --git a/extensions/voice-call/openclaw.plugin.json b/extensions/voice-call/openclaw.plugin.json
index ff85a30a947..0076fc3c479 100644
--- a/extensions/voice-call/openclaw.plugin.json
+++ b/extensions/voice-call/openclaw.plugin.json
@@ -41,6 +41,16 @@
       "label": "Twilio Auth Token",
       "sensitive": true
     },
+    "twilio.region": {
+      "label": "Twilio Region",
+      "help": "Processing region: ie1 (Ireland) or au1 (Australia). Omit for US1 (default). Requires region-specific auth credentials.",
+      "advanced": true
+    },
+    "twilio.edge": {
+      "label": "Twilio Edge Location",
+      "help": "Edge location (e.g. dublin, sydney, ashburn). Auto-inferred from region if omitted.",
+      "advanced": true
+    },
     "outbound.defaultMode": {
       "label": "Default Call Mode"
     },
@@ -194,6 +204,14 @@
           },
           "authToken": {
             "type": "string"
+          },
+          "region": {
+            "type": "string",
+            "pattern": "^[a-z0-9]+$"
+          },
+          "edge": {
+            "type": "string",
+            "pattern": "^[a-z0-9-]+$"
           }
         }
       },
diff --git a/extensions/voice-call/src/config.ts b/extensions/voice-call/src/config.ts
index 5ecd4f01bd3..dd15c37b6f6 100644
--- a/extensions/voice-call/src/config.ts
+++ b/extensions/voice-call/src/config.ts
@@ -48,8 +48,34 @@ export const TwilioConfigSchema = z
   .object({
     /** Twilio Account SID */
     accountSid: z.string().min(1).optional(),
-    /** Twilio Auth Token */
+    /** Twilio Auth Token (must match the target region — each region has its own credentials) */
     authToken: z.string().min(1).optional(),
+    /**
+     * Twilio Region for data processing (e.g. "ie1" for Ireland, "au1" for Australia).
+     * When set, API calls target `api.{edge}.{region}.twilio.com` instead of the
+     * default US1 endpoint (`api.twilio.com`). Requires region-specific auth credentials.
+     *
+     * Supported processing regions: "ie1" (Ireland), "au1" (Australia).
+     * US1 is the default when region is not set.
+     *
+     * @see https://www.twilio.com/docs/global-infrastructure/understanding-twilio-regions
+     * @see https://www.twilio.com/docs/global-infrastructure/api-domain-migration-guide
+     */
+    region: z
+      .string()
+      .regex(/^[a-z0-9]+$/)
+      .optional(),
+    /**
+     * Twilio Edge Location (e.g. "dublin", "sydney", "ashburn").
+     * Used together with `region` to construct the API FQDN.
+     * Auto-inferred from region if omitted (ie1→dublin, au1→sydney).
+     * Must be specified with `region` to avoid the deprecated domain pattern.
+     * @see https://www.twilio.com/docs/global-infrastructure/understanding-edge-locations
+     */
+    edge: z
+      .string()
+      .regex(/^[a-z0-9-]+$/)
+      .optional(),
   })
   .strict();
 export type TwilioConfig = z.infer<typeof TwilioConfigSchema>;
@@ -418,6 +444,8 @@ export function resolveVoiceCallConfig(config: VoiceCallConfigInput): VoiceCallC
     resolved.twilio = resolved.twilio ?? {};
     resolved.twilio.accountSid = resolved.twilio.accountSid ?? process.env.TWILIO_ACCOUNT_SID;
     resolved.twilio.authToken = resolved.twilio.authToken ?? process.env.TWILIO_AUTH_TOKEN;
+    resolved.twilio.region = resolved.twilio.region ?? process.env.TWILIO_REGION;
+    resolved.twilio.edge = resolved.twilio.edge ?? process.env.TWILIO_EDGE;
   }
 
   // Plivo
diff --git a/extensions/voice-call/src/providers/twilio.test.ts b/extensions/voice-call/src/providers/twilio.test.ts
index 4e23783b93a..e0e17a0d66e 100644
--- a/extensions/voice-call/src/providers/twilio.test.ts
+++ b/extensions/voice-call/src/providers/twilio.test.ts
@@ -21,6 +21,63 @@ function createContext(rawBody: string, query?: WebhookContext["query"]): Webhoo
   };
 }
 
+describe("TwilioProvider.buildBaseUrl", () => {
+  it("defaults to US1 when no region is specified", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123")).toBe(
+      "https://api.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("defaults to US1 when region and edge are both undefined", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123", undefined, undefined)).toBe(
+      "https://api.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("builds IE1 Dublin URL when region=ie1 and edge=dublin", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123", "ie1", "dublin")).toBe(
+      "https://api.dublin.ie1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("builds AU1 Sydney URL when region=au1 and edge=sydney", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123", "au1", "sydney")).toBe(
+      "https://api.sydney.au1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("builds URL with explicit edge and region for any combination", () => {
+    // Even for non-standard combinations, both edge and region are used
+    expect(TwilioProvider.buildBaseUrl("AC123", "jp1", "tokyo")).toBe(
+      "https://api.tokyo.jp1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("infers default edge for supported processing regions when edge is omitted", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123", "ie1")).toBe(
+      "https://api.dublin.ie1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+    expect(TwilioProvider.buildBaseUrl("AC123", "au1")).toBe(
+      "https://api.sydney.au1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+    expect(TwilioProvider.buildBaseUrl("AC123", "us1")).toBe(
+      "https://api.ashburn.us1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("falls back to ashburn edge for unknown regions", () => {
+    expect(TwilioProvider.buildBaseUrl("AC123", "xx9")).toBe(
+      "https://api.ashburn.xx9.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+
+  it("allows overriding the default edge for a region", () => {
+    // Use ashburn edge with IE1 region (unusual but valid)
+    expect(TwilioProvider.buildBaseUrl("AC123", "ie1", "ashburn")).toBe(
+      "https://api.ashburn.ie1.twilio.com/2010-04-01/Accounts/AC123",
+    );
+  });
+});
 function expectStreamingTwiml(body: string) {
   expect(body).toContain(STREAM_URL);
   expect(body).toContain('<Parameter name="token" value="');
@@ -28,6 +85,16 @@ function expectStreamingTwiml(body: string) {
 }
 
 describe("TwilioProvider", () => {
+  it("uses regional base URL when region/edge are configured", () => {
+    const provider = new TwilioProvider(
+      { accountSid: "AC123", authToken: "secret", region: "ie1", edge: "dublin" },
+      { publicUrl: "https://example.ngrok.app", streamPath: "/voice/stream" },
+    );
+    // Provider should have constructed the correct regional base URL internally.
+    // We verify indirectly: the provider should initialize without error.
+    expect(provider.name).toBe("twilio");
+  });
+
   it("returns streaming TwiML for outbound conversation calls before in-progress", () => {
     const provider = createProvider();
     const ctx = createContext("CallStatus=initiated&Direction=outbound-api&CallSid=CA123", {
diff --git a/extensions/voice-call/src/providers/twilio.ts b/extensions/voice-call/src/providers/twilio.ts
index e09367eb3fa..92d3f1c9b1a 100644
--- a/extensions/voice-call/src/providers/twilio.ts
+++ b/extensions/voice-call/src/providers/twilio.ts
@@ -144,7 +144,7 @@ export class TwilioProvider implements VoiceCallProvider {
 
     this.accountSid = config.accountSid;
     this.authToken = config.authToken;
-    this.baseUrl = `https://api.twilio.com/2010-04-01/Accounts/${this.accountSid}`;
+    this.baseUrl = TwilioProvider.buildBaseUrl(this.accountSid, config.region, config.edge);
     this.options = options;
 
     if (options.publicUrl) {
@@ -152,6 +152,61 @@ export class TwilioProvider implements VoiceCallProvider {
     }
   }
 
+  /**
+   * Build the Twilio API base URL for a given region/edge combination.
+   *
+   * FQDN format: `{product}.{edge}.{region}.twilio.com`
+   *
+   * When both region and edge are specified, targets that specific region.
+   * When only region is specified, edge defaults to the canonical edge for that region.
+   * When neither is specified, falls back to the default US1 endpoint (`api.twilio.com`).
+   *
+   * Supported processing regions (as of 2026):
+   * - **us1** (default) — United States
+   * - **ie1** — Ireland (edge: dublin)
+   * - **au1** — Australia (edge: sydney)
+   *
+   * Note: The legacy `api.{region}.twilio.com` pattern (without edge) is deprecated
+   * and will stop working on April 28, 2026. This method always includes the edge
+   * in the FQDN to use the correct, non-deprecated format.
+   *
+   * @see https://www.twilio.com/docs/global-infrastructure/using-the-twilio-rest-api-in-a-non-us-region
+   * @see https://www.twilio.com/docs/global-infrastructure/api-domain-migration-guide
+   */
+  static buildBaseUrl(accountSid: string, region?: string, edge?: string): string {
+    if (!region) {
+      // Default US1 endpoint — no region/edge needed
+      return `https://api.twilio.com/2010-04-01/Accounts/${accountSid}`;
+    }
+
+    // When region is set, edge must also be specified to avoid the deprecated
+    // api.{region}.twilio.com pattern (which routes to US1 and stops working
+    // April 28, 2026). If the user omitted edge, infer the canonical one.
+    const resolvedEdge = edge || TwilioProvider.defaultEdgeForRegion(region);
+    const host = `api.${resolvedEdge}.${region}.twilio.com`;
+    return `https://${host}/2010-04-01/Accounts/${accountSid}`;
+  }
+
+  /**
+   * Map Twilio processing regions to their canonical edge location.
+   * Used as fallback when `edge` is not explicitly configured.
+   *
+   * Only includes regions that support regional data processing.
+   * Legacy region codes (br1, de1, jp1, sg1, us2) are NOT included —
+   * those were edge-only shortcuts that always processed in US1 and are
+   * deprecated as of April 28, 2026.
+   *
+   * @see https://www.twilio.com/docs/global-infrastructure/api-domain-migration-guide
+   */
+  private static defaultEdgeForRegion(region: string): string {
+    const defaults: Record<string, string> = {
+      ie1: "dublin",
+      au1: "sydney",
+      us1: "ashburn",
+    };
+    return defaults[region.toLowerCase()] ?? "ashburn";
+  }
+
   setPublicUrl(url: string): void {
     this.currentPublicUrl = url;
   }
@@ -676,7 +731,7 @@ export class TwilioProvider implements VoiceCallProvider {
           Authorization: `Basic ${Buffer.from(`${this.accountSid}:${this.authToken}`).toString("base64")}`,
         },
         allowNotFound: true,
-        allowedHostnames: ["api.twilio.com"],
+        allowedHostnames: [new URL(this.baseUrl).hostname],
         auditContext: "twilio-get-call-status",
         errorPrefix: "Twilio get call status error",
       });
diff --git a/extensions/voice-call/src/runtime.ts b/extensions/voice-call/src/runtime.ts
index 384ac209a76..8a038c2b152 100644
--- a/extensions/voice-call/src/runtime.ts
+++ b/extensions/voice-call/src/runtime.ts
@@ -103,6 +103,8 @@ function resolveProvider(config: VoiceCallConfig): VoiceCallProvider {
         {
           accountSid: config.twilio?.accountSid,
           authToken: config.twilio?.authToken,
+          region: config.twilio?.region,
+          edge: config.twilio?.edge,
         },
         {
           allowNgrokFreeTierLoopbackBypass,
diff --git a/skills/voice-call/SKILL.md b/skills/voice-call/SKILL.md
index 7cfb5769252..bfc0a516596 100644
--- a/skills/voice-call/SKILL.md
+++ b/skills/voice-call/SKILL.md
@@ -39,7 +39,7 @@ Notes:
 
 - Requires the voice-call plugin to be enabled.
 - Plugin config lives under `plugins.entries.voice-call.config`.
-- Twilio config: `provider: "twilio"` + `twilio.accountSid/authToken` + `fromNumber`.
+- Twilio config: `provider: "twilio"` + `twilio.accountSid/authToken` + `fromNumber`. Optional `twilio.region` (ie1, au1) and `twilio.edge` (dublin, sydney) for non-US regions.
 - Telnyx config: `provider: "telnyx"` + `telnyx.apiKey/connectionId` + `fromNumber`.
 - Plivo config: `provider: "plivo"` + `plivo.authId/authToken` + `fromNumber`.
 - Dev fallback: `provider: "mock"` (no network).